Presentation day

Tuesday  9:10 AM

TITLE

Luminescent Gold Nanoparticles: a Antifouling Surface Ligand for Minimizing Nonspecific Serum Protein Adsorption

Abstract

While these organic or polymeric ligands have been widely used to stabilize inorganic
nanoparticles (NPs) in the physiological environment, they seldom render the NPs new functionalities,
which often need to be achieved by integrating nanostructures with different functionalities together. In the
past decade, we have developed a class of luminescent gold nanoparticles coated with a monolayer of
glutathione ligand and found that those NPs exhibited high resistance to serum protein adsorption. Herein,
we reported that these gold nanoparticles can serve as surface ligands and self-assmeble to the surface of
superparamagnetic iron oxide nanoparticles (SPIONs). The obtained hybrid nanoparticles not only carried
with both fluorescent and magentic properties but also have high resistance to the serum protein adsorption
in the native physiological environment (Figure 1). This unique synergy offered by antifouling luminescent
GS-AuNPs in enhanced functionalities and physiological stabilities opens up a new pathway to design
multimodal nanoprobes for in vivo biomedical imaging.