Dr. Wang, Guoping
CV
Apr. 2014–present
Special postdoctoral researcher, Bioengineering Lab, RIKEN, Japan
Apr. 2013–Mar. 2014
JSPS Postdoctoral Fellow, Department of Chemistry, University of California, Riverside, USA
Apr. 2010–Mar. 2013
Ph.D. in Materials Chemistry, Graduate School of Chemical Sciences and Engineering, Hokkaido University, Japan
Sep. 2009–Mar. 2010
Research Assistant, Environmental Microanalysis & Monitoring Lab, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, China
Aug. 2007–Aug. 2009
M.Sc. in Bionanotechnology, Department of Bionano Sciences, The Graduate School, Hanyang University, South Korea
Sep. 2003–Jul. 2007
B.E. in Chemical Engineering, Department of Chemical Engineering, Qufu Normal University, China
Presentation day
Wednesday 8:30 PM
TITLE
Programmable anisotropic self-assembly of gold nanorods regulated by DNA terminal base pairing
Abstract
Gold nanoparticles covered by full-match double-stranded DNA (dsDNA-GNPs) undergo
rapid aggregation in a non-crosslinking manner at high ionic strength. In contrast, dsDNA-GNPs stay
dispersed when dsDNA has a terminal single-base mismatch.[1] Here we demonstrate that gold nanorods
(GNRs) regiospecifically modified with dsDNA can produce non-crosslinked assemblies in an orientationcontrolled
fashion. TEM imaging revealed that the GNRs formed side-by-side assemblies when the dsDNA
on the side of GNR was fully matched and that on the ends was terminal-mismatched (Scheme 1a). In
contrast, end-to-end assemblies emerged with fully-matched dsDNA on the ends and terminal-mismatched
one on the side (Scheme 1b). The controlled assembling processes were driven by blunt-end stacking on
an intentional region of the GNR, along with the fraying motion of terminal mismatched bases on the other
region. Hg(II)-mediated base pairing of T-T mismatch can simultaneously alternate the nature of the side
and the end regions,[2] thereby giving rise to direct transition between non-crosslinked side-by-side and
end-to-end assembly. This new approach for programmed self-assembly of anisotropic nanoparticles
should overcome the limitation in rapid transformation of assembly configuration.
Literatures
-
K. Sato, K. Hosokawa, M. Maeda, J. Am. Chem. Soc. 2003, 125, 8101.
-
N. Kanayama, T. Takarada, M. Fujita, M. Maeda, Chem. Eur. J. 2013, 19, 10794.