Dr. Sato, Takahiro
Presentation day
Wednesday 8:50 AM
TITLE
Hydrophobe-uptake micellization of low molar mass and polymer surfactants in aqueous media
Abstract
Recently, polymer micelles have attracted considerable attention for their potential
applications to nano-carriers and nano-reactors. The drug delivery system is a typical example of the nanocarrier.
When surfactants are utilized as nano-carriers and nano-reactors, hydrophobe-uptake micellization is a
basically important phenomenon, but it has not been investigated in detail so far. The following reasons
may be in order.
Near the critical micelle concentration (cmc), the micelle becomes less stable and sensitive to the solution
temperature. Thus, it is difficult to prepare samples of hydrophobe-uptake micelles near the cmc for cryotransmission
electron microscopy. Light scattering measurements also encounter difficulty of anomalous
scattering for hydrophobe-uptake micelles near the cmc. In this study, we have investigated the
hydrophobe-uptake micellization behavior of low molar mass surfactants near the cmc by combining static
and dynamic light scattering.
For polymer micelles, the cmc is so dilute that we do not observe anomalous scattering for hydrophobeuptake
polymer micelles under the normal condition. However, polymer micelles formed by amphiphilic
random and alternative copolymers are much more complex in their structure than low molar mass
surfactant micelles. Therefore, the structure of hydrophobe-uptake polymer micelles has not investigated in
detail. The present study has undertaken small-angle X-ray and light scattering experiments to reveal the
structure of hydrophobe-uptake micelles formed by an amphiphilic alternating copolymer.
CV
1985 PhD, Osaka University, Japan
1985 Visiting Scientist, Polymers Division, National Bureau of Standards, USA.
1987 Assistant Professor, Department of Macromolecular Science, Osaka University
1996 Associate Professor, Department of Macromolecular Science, Osaka University
2002 Professor, Department of Macromolecular Science, Osaka University
Literatures
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Rintaro Takahashi, Takahiro Sato, Ken Terao, and Shin-ichi Yusa, "Intermolecular Interactions and Self-Assembly in Aqueous Solution of a Mixture of Anionic–Neutral and Cationic–Neutral Block Copolymers," Macromolecules, in press.
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Ken Morishima and Takahiro Sato, “Light Scattering from Hydrophobe-Uptake Spherical Micelles near the Critical Micelle Concentration,” Langmuir, 30, 11513−11519 (2014).
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Rintaro Takahashi, Xing-Ping Qiu, Na Xue, Takahiro Sato, Ken Terao, and Francoise M. Winnik, “Self-Association of the Thermosensitive Block Copolymer Poly(2-isopropyl-2-oxazoline)‑b‑poly(N‑isopropylacrylamide) in Water−Methanol Mixtures,” Macromolecules, 47, 6900−6910 (2014).
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Takashi Okuhara, Akihito Hashidzume, Ken Terao, Takahiro Sato, “Aggregation and Phase Separation of Hydrophilically Modified Poly(dimethylsiloxane) in Methanol-water Mixtures,” Polym. J., 46, 264–271 (2014).
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Tomoe Arai, Makoto Masaoka, Tomohiro Michitaka, Yosuke Watanabe, Akihito Hashidzume, Takahiro Sato, “Aggregation Behavior of Polystyrene-based Amphiphilic Diblock Copolymers in Organic Media,” Polym. J., 46(3), 189-194 (2014).
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Takahiro Sato, Kohei Tanaka, Akiko Toyokura, Rika Mori, Rintaro, Takahashi, Ken Terao, and Shin-ichi Yusa, “Self-Association of a Thermosensitive Amphiphilic Block Copolymer Poly(N-isopropylacrylamide)-b-Poly(N-vinyl-2-pyrrolidone) in Aqueous Solution upon Heating,” Macromolecules, 46 (1), 226–235 (2013).
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Rintaro Takahashi, Takahiro Sato, Ken Terao, Xing-Ping Qiu, and Françoise M. Winnik, “Self-Association of a Thermosensitive Poly(alkyl-2-oxazoline) Block Copolymer in Aqueous Solution,” Macromolecules, 45, 6111−6119 (2012).
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Motoki Ueda, Akihito Hashidzume, and Takahiro Sato, “Unicore-Multicore Transition of the Micelle Formed by an Amphiphilic Alternating Copolymer in Aqueous Media