Dr. Li, Yongsheng
Institution
School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, China.
Presentation day
Thursday 4:00 PM
TITLE
A simple approach to synthesize multifunctional hybrid nanocomposites for biomedical applications
Abstract
A simple and controllable synthesis route has been successfully developed to fabricate
various hybrid nanocomposites based on the self-assembly of block copolymers, PS-b-PAA, and the
subsequent shell cross-linking with organic silanes. It is verified that both hydrophobic functional molecules
or/and nanoparticles could be easily encapsulated into the cores of the micelles to form functional
nanocomposites. Importantly, significantly enhanced structure stability and monodispersivity of the
nanocomposites, as well as the convenient modification, were achieved owing to the organic-inorganic
layer formation from the micelle shell cross-linking and the introduction of –SH groups on the outer surface.
Therefore, it creates a universal approach to design and construct core-shell structured hybrid
nanocompoistes, which present great potentials in imaging, diagnosis and therapy on cancer.
CV
Literatures
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Dong, W.; Li, Y.; Niu, D.; Ma, Z.; Gu, J.; Chen, Y.; Zhao, W.; Liu, X.; Liu, C.; Shi, J., Facile Synthesis of Monodisperse Superparamagnetic Fe3O4 Core@hybrid@Au Shell Nanocomposite for Bimodal Imaging and Photothermal Therapy. Adv. Mater. 2011, 23 (45), 5392-5397
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Niu, D.; Wang, X.; Li, Y.; Zheng, Y.; Li, F.; Chen, H.; Gu, J.; Zhao, W.; Shi, J., Facile Synthesis of Magnetite/Perfluorocarbon Co-Loaded Organic/Inorganic Hybrid Vesicles for Dual-Modality Ultrasound/Magnetic Resonance Imaging and Imaging-Guided High-Intensity Focused Ultrasound Ablation. Adv. Mater. 2013, 25 (19), 2686-2692.
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