Presentation day

Thursday  7:20 PM

 

TITLE

Impact of packing parameter of synthetic amphiphiles in the design of drug and gene delivery　systems

 

Abstract

Drug and gene delivery systems rely on the ability of natural and synthetic amphiphile
assemblies to pack and deliver drugs and genes across various delivery barriers in the organism. Since it is
rather difficult for a single amphiphile to ensure successful passage through multiple barriers and delivery
of their cargo into target cells, mixtures of amphiphiles with different packing parameters are used in
everyday practice. [1-3]
Throughout the last decade our group synthesized amphiphiles with a wide range of packing parameters,
from single chain amphiphiles, gemini surfactants, lipids and lipophilic oligomers, which were used
successfully in the design of efficient drug and gene delivery systems [1-8]. The talk will emphasize how the
packing parameter of selected amphiphile(s) influenced the loading and release of selected drugs and
nucleic acids, with an emphasis on structure-activity and structure-property relationships within each class
of amphiphiles. We will also present our very recent efforts towards interfacial engineering of these
materials for both drug and gene delivery.