Dr. Gale, Philip
Institution
Chemistry, University of Southampton, Southampton, Hants, United Kingdom.
Presentation day
Tuesday 1:20 PM
TITLE
Anion transport across varying lipid membranes
Abstract
Most studies on synthetic transmembrane anion transporters are condcuted either in a single lipid (e.g.
POPC) or a mixture of lipid and cholesterol. We wished to explore how synthetic anion transporters would
perform in a range of different lipid bilayers. The anion transport properties of a range of alkyl-substituted
phenylthioureas were tested in vesicles of different lipid composition. Although changes in the bilayer
affected the rate of transport for all compounds in the series, the ‘ideal’ log P for peak activity did not
change depending on the composition of the bilayers tested.[1]
Reference
1. M.J. Spooner and P.A. Gale, Chem. Commun., 2015, 51, 4883.
CV
2014 Doctor of Science (DSc), Wadham College, University of Oxford.
2010- Head of Chemistry, University of Southampton.
2007 Personal Chair in Supramolecular Chemistry.
2005 Reader in Supramolecular Chemistry.
2002-2005 Senior Lecturer and Royal Society URF, School of Chemistry, University of Southampton.
1999-2002 Lecturer and Royal Society URF, Department of Chemistry, University of Southampton.
1997-1999 Royal Society University Research Fellowship, Inorganic Chemistry Laboratory, Oxford.
1995-1997 Fulbright Research Scholarship to work with Prof. Jonathan L. Sessler at The University of Texas at Austin.
1992-1995 D.Phil. Linacre College, University of Oxford. Supervisor: Prof. Paul D. Beer.
1988-1992 Wadham College, Oxford 1992: BA (Hons) Chemistry Class 2:1. (1995: MA).
Literatures
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“Dynamic covalent transport of amino acids across lipid bilayers” X. Wu, N. Busschaert, N.J. Wells, Y.-B. Jiang and P.A. Gale, J. Am. Chem. Soc., 2015, 137, 1476-1484.
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“Anion transport across varying lipid membranes – the effect of lipophilicity” M.J. Spooner and P.A. Gale, Chem. Commun., 2015, 51, 4883-4886.
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“Synthetic ion transporters can induce apoptosis by facilitating chloride anion transport into cells” S.K. Ko, S.K. Kim, A. Share, V.M. Lynch, J. Park, W. Namkung, W. Van Rossom, N. Busschaert, P.A. Gale, J.L. Sessler and I. Shin, Nature Chem., 2014, 6, 885-892.
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“Synthetic transporters for sulfate: a new method for the direct detection of lipid bilayer sulfate transport.” N. Busschaert, L.E. Karagiannidis, M. Wenzel, C.J.E. Haynes, N.J. Wells, P.G. Young, D. Makuc, J. Plavec, K.A. Jolliffe and P.A. Gale, Chem. Sci., 2014, 5, 1118-1127.