Dr. Sakurai, Kazuo
Institution
Chemistry and Biochemistry, University of Kitakyushu, Kitakyushu, Fukuoka,
Japan.
Literatures
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Zhang, Q., Ichimaru, N., Higuchi, S., Cai, S., Hou, J., Fujino, M., Nonomura, N., Kobayashi, M., Ando, H. & Uno, A. (2015) Permanent acceptance of mouse cardiac allografts with CD40 siRNA to induce regulatory myeloid cells by use of a novel polysaccharide siRNA delivery system, Gene therapy -Nature. 22, 1–10.
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Sanada, Y., Sakamoto, S., Shiomi, T., Okobira, T., Mylonas, E., Ohta, N., Yagi, N., Nishikawa, M., Akiba, I., Takakura, Y. & Sakurai, K. (2014) X-ray scattering from immunostimulatory tetrapod-shaped DNA in aqueous solution to explore its biological activity-conformation relationship, J Phys Chem B. 118, 10373-9.
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Kobiyama, K., Aoshi, T., Narita, H., Kuroda, E., Hayashi, M., Tetsutani, K., Koyama, S., Mochizuki, S., Sakurai, K. & Katakai, Y. (2014) Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist, PNAS. 111, 3086-3091.
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Fujii, S., Nishina, K., Yamada, S., Mochizuki, S., Ohta, N., Takahara, A. & Sakurai, K. (2014) Micelles consisting of choline phosphate-bearing Calix [4] arene lipids, Soft matter. 10, 8216-8223.
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Sanada, Y., Akiba, I., Sakurai, K., Shiraishi, K., Yokoyama, M., Mylonas, E., Ohta, N., Yagi, N., Shinohara, Y. & Amemiya, Y. (2013) Hydrophobic Molecules Infiltrating into the Poly(ethylene glycol) Domain of the Core/Shell Interface of a Polymeric Micelle: Evidence Obtained with Anomalous Small-Angle X-ray Scattering, JACS. 135, 2574-2582.
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Fujii, S., Sakurai, K., Okobira, T., Ohta, N. & Takahara, A. (2013) Synthesis and Characterization of a Calix[4]arene Amphiphilie Bearing Cysteine and Uniform Au Nanoparticle Formation Templated by its Four Cysteine Moieties, Langmuir.
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Fujii, S., Sanada, Y., Nishimura, T., Akiba, I., Sakurai, K., Yagi, N. & Mylonas, E. (2012) A stimulus-responsive shape-persistent micelle bearing a calix[4]arene building block: reversible pH-dependent transition between spherical and cylindrical forms, Langmuir. 28, 3092-101.
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Takedatsu, H., Mitsuyama, K., Mochizuki, S., Kobayashi, T., Sakurai, K., Takeda, H., Fujiyama, Y., Koyama, Y., Nishihira, J. & Sata, M. (2012) A new therapeutic approach using a schizophyllan-based drug delivery system for inflammatory bowel disease, Molecular Therapy -Nature. 20, 1234-1241.
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Mochizuki, S. & Sakurai, K. (2011) Dectin-1 targeting delivery of TNF-α antisense ODNs complexed with β-1, 3-glucan protects mice from LPS-induced hepatitis, Journal of Controlled Release. 151, 155-161.
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Mizu, M., Koumoto, K., Anada, T., Matsumoto, T., Numata, M., Shinkai, S., Nagasaki, T. & Sakurai, K. (2004) A polysaccharide carrier for immunostimulatory CpG DNAs to enhance cytokine secretion, JACS. 126, 8372-3.
Career
1982 BS, Polymer Science, Department of Science, Osaka University.
1984 MS, Polymer Science, Department of Science, Osaka University.
1996 PhD, Polymer Science, Department of Science, Osaka University.
1985-1990 Research Scientist in Kanebo Ltd.,
1990-1993 Visiting Researcher in University of Mass, Amherst
1994-1995 Research Scientist in Kanebo Ltd.,
1995-2000 Research Group leader of Kanebo Ltd.,
1999-2000 JST Shinkai ICORP project Group leader
2000-2001 JST PREST Researcher
2001- Professor (The University of Kitakyushu)
Presentation day
Wednesday 8:00 AM
TITLE
Shape Persistence Micelles Having the Same Aggregations with the Platonic Solids
Abstract
A series of calix[4]arene-based lipids with alkyl chains of varying length were newly
synthesized and found that some of them form spherical micelles with a defined aggregation number.
These aggregation numbers are 6, 8, 12, and 20, interestingly coinciding the numbers of the Platonic
solids. Synchrotron small-angle X-ray scattering (SAXS) patterns exhibited a sharp intensity minimum,
indicating high symmetry and shape monodispersity. The size monodispersity of the micelles was
confirmed with analytical ultracentrifugation and asymmetric filed flow fractionation. The present results
indicate that a suitable combination of tail length, head volume, and rigidity of the building block is
necessary to attain the shape persistency. With a shape determination program of Dummy and molecular
dynamics calculation, the micellar architecture was determined and an atomic scale model to reproduce
SAXS profile was constructed.
We have a hypothesis that can rationalize why the aggregation numbers are taking such a discreet manner
and chosen from the numbers of the Platonic solids; the aggregation number is determined by the J. J.
Thomson’s theorem to determine the minimum electrostatic potential energy configuration of N electrons on
the sphere surface that repel each other. We suppose this can be extended to the other spherical micelles
when the aggregation numbers are small enough.